Secnidazole

SKU : AP008
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CAS number

3366-95-8

molecular formula

C7H11N3O3

standard

99% MIN99%min

Package

25kg/drum
ITEMS LIMIT
Description Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a longer terminal elimination half-life (approximately 17 to 29 hours) than commonly used drugs in this class. in patients with intestinal amoebiasis or giardiasis, clinical or parasistological cure rates of 80 to 100% are achieved after treatment with a single dose of secnidazole 2g (30 mg/kg in children), similar to the response rates achieved with multiple dosage regimens of metronidazole or tinidazole.
Appearance A white to pale yellow crystal or crystalline powder
Solubility

Freely soluble in Ethanol, soluble in chloroform, sparinglyoluble in water or ethyl ether,

freely soluble in dilute acid.

Ultraviolet absorbance The absorbance (E 1cm 1%) of the solution(13ug/ml) in hydrochloride acid(9-1000) should be 331-349 at 277nm
Identification Chemical reaction: Matches with standard
UV: Max 277 nm, min 241 nm
IR:  Matches with standard
Melting range 68 to 78 °C
Clarity of Ethanol solution 2% w/v in Ethanol should be clear
Solubility in dilute acid 5% w/v in 1 N HC1 should be freely soluble
pH 5.5-7.5, determined in 1% w/v solution in water
Water content (KF) ≤6.0%
Residue on ignition ≤0.1%
Heavy metals ≤20ppm
Related substances 2-methyl-5-nitronimidazole: ≤0.5%
Any other individual impurity:  ≤0.5%
Total impurities ≤1.0%
Residual solvent Dichloromethane ≤300ppm
Ethyl acetate≤1000ppm
Assay (on anhydrous basis) 98.0% ~ 102.0%

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